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Huntington’s Disease: An Efficacy Study of High Dose CoQ10 Formulations

Huntington’s Disease, (HD), is a genetic brain, (neurological), disease that affects both mind and body. Huntington’s Disease is characterized by an inability to control movements and ..

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Omega 3 and Bipolar Disorder Clinical Trial at Harvard Medical School

A double-blind, placebo-controlled trial of Omega-3 fatty acids in bipolar disorder was recently conducted by Brigham and Women's Hospital, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.

BACKGROUND: Omega-3 fatty acids may inhibit neuronal signal transduction pathways in a manner similar to that of lithium carbonate and valproate, two effective treatments for bipolar disorder. The present study was performed to examine whether Omega-3 fatty acids also exhibit mood-stabilizing properties in bipolar disorder.

METHODS: A 4-month, double-blind, placebo-controlled study, comparing omega-3 fatty acids (9.6 g/d) vs placebo (olive oil), in addition to usual treatment, in 30 patients with bipolar disorder.

RESULTS: A Kaplan-Meier survival analysis of the cohort found that the Omega-3 fatty acid patient group had a significantly longer period of remission than the placebo group (P = .002; Mantel-Cox). In addition, for nearly every other outcome measure, the Omega-3 fatty acid group performed better than the placebo group.

CONCLUSION: Omega-3 fatty acids were well tolerated and improved the short-term course of illness in this preliminary study of patients with bipolar disorder.

Stoll AL, Severus WE, Freeman MP, Rueter S, Zboyan HA, Diamond E, Cress KK, Marangell LB. Brigham and Women's Hospital, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.


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